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plasmid construction

mRNA Plasmid Traceability Synthesis

L-star organism with its professional plasmid construction team in the poly(A)-rich sequence of mRNA template plasmid synthesis and construction showed excellent ability. Focus on providing customized and efficient solutions for companies in the field of nucleic acid drugs and cell gene therapy. The team is committed to solving the key challenges and technical problems in the process of plasmid construction, ensuring high quality and reliable template plasmid services for customers, helping customers overcome the challenges in the research and development stage, and accelerating the innovation and development of nucleic acid drugs and cell therapy.

● mRNA plasmid customization design

▪enzyme cleavage site
▪Ori Region

sequence optimization

Non-essential sequence deletion

Non-essential sequence deletion

▪PolyA stabilizer
▪Control sub

Core Components Added

● Precise synthesis of mRNA plasmids

L-star biology provides advanced mRNA plasmid precise synthesis services, relying on our exclusive plasmid skeleton library, equipped with a variety of linearized enzyme cutting sites and diversified poly(A) sequence design. These designs cover different lengths and patterns to meet the specific needs of various customers for rapid mRNA plasmid synthesis. In addition, with our extensive experience in plasmid quality control (QC), we are able to provide a high level of Poly(A)-tailed Sanger sequencing solutions. This service is designed to enable accurate Sanger sequencing of the Poly(A) tail in mRNA plasmids, ensuring high quality and accuracy of the synthesized product.

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Continuous Poly(A) tail synthesis and Sanger sequencing

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Discontinuous Poly(A) Tail Synthesis and Sanger Sequencing

L-Star Bio provides professional traceability synthesis services for biopharmaceutical enterprises to meet the strict requirements of drug declaration. We have established a strict quality management system in accordance with the rules for the declaration of biological drugs to ensure the compliance, reliability, authenticity and traceability of the entire production process, and provide pharmaceutical research and development enterprises with compliance reports that are applicable to review standards and meet audit requirements.
In addition, taking into account the increased demand for drug exports to countries along the Belt and Road, L-Star Bio also provides plasmid products that meet halal certification requirements. This service includes the provision of supporting documents, such as a no-epidemic area declaration and a no-pig source declaration, upon completion of the project, to ensure that the product meets the specific regulations and standards of the export destination. Through these comprehensive services, L-Star Bio is committed to supporting the needs of global pharmaceutical companies in drug development and export, and ensuring the international compliance and market acceptance of products.

● Traceability service quality assurance

Professional technical team, project management and whole process service of experimental process

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Perfect qualification

systematic training of laboratory personnel

permanent preservation of training materials

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Complete certification

Periodic certification and verification of key instruments

Clear traceability of experimental materials

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Process control

Quality department monitoring the whole process

data permission hierarchical management

Complete records of the experimental process

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Record keeping

Project Individual Archive Management

Records kept free for ten years

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Audit supporting

Compliant with IND reporting criteria

Support on-site audit

Biochemical Platform

activity

Residual dsRNA

residual protein

molecular platform

Residual DNA

gene identification

Quick test for mycoplasma

gene sequencing

Residual RNA

Physical and chemical platform

integrity

Purity/Content

Residue

particle size

superhelical scale

Cap/Tail

insoluble particles

zeta potential

Microbial Platform

endotoxin

Microbial limit

Sterile

insoluble particles

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